While THC functions as a CB1 receptor agonist, THCV acts as an inverse agonist, binding to the same receptor but inducing an opposing pharmacological response. In contrast to THC, THCV may have appetite-suppressing properties.
In a study, individuals who were regular THC users received an oral dose of THCV shortly before THC administration. As a result, none of them reported experiencing the typical effects of THC. However, due to the scarcity of THCV in most cannabis strains, it is challenging to consume a sufficient amount to counteract the effects of THC in real-world scenarios.
IS THCV LEGAL?
THCV, despite its molecular resemblance to THC, exhibits distinct effects within the body and is not classified as a controlled substance in the United States. Federal legality of THCV is contingent upon its extraction from hemp plants with THC concentrations below 0.3%. Furthermore, at the state level, THCV is permissible in all cannabis strains where medical and/or adult use is legally recognized.
The Benefits Of THCV
THCV is currently under investigation as a potential remedy for obesity due to its potential appetite-suppressing effects. Studies have indicated that it could potentially reduce food consumption and initiate weight reduction.
HOW DOES THCV WORK IN THE BODY?
THCV, similar to THC and CBD, potentially induces relaxation by interacting with chemical receptors in various bodily systems. The main receptors involved are CB1 and CB2, constituting the Endocannabinoid System (ECS).
CB1 receptors are distributed throughout the body, with a higher concentration in the brain and nervous system, while CB2 receptors are predominantly found in the immune system. In low doses, THCV acts as a CB1 receptor antagonist, blocking certain effects caused by THC, such as increased appetite.
However, at higher doses, THCV activates both CB1 and CB2 receptors, producing effects that more closely resemble THC.
Where To Find THCV
THCV is not typically found in high concentrations in hemp, but there is growing interest in high-THCV cultivars. Consequently, it is becoming somewhat more accessible to find strains that have been selectively bred to contain this intriguing cannabinoid.